Benzodiazepines Drug-Drug Interaction

Benzodiazepines Drug-Drug Interaction

+ CNS depressants/alcohol > additive > increase CNS depression

+ CYP3A4 inhibitor > increase plasma [benzodiazepiens]

examples include:

azole antifungal agents (itraconazole, ketoconazole)

diltiazem

SSRIs (fluoxetine, fluvoxamine)

grapefruit juice

isoniazid

erythromycin

nefazodone

non-nucleoside reverse transcriptase inhibitors (delavirdine, efavirenz)

protease inhribitors (indinavir)

+ CYP3A4 inducer > decrease plasma [benzodiazepines]

examples include carbamazepine and rifampin

+ flumazenil = antagonism

*Combination of anxiolytic drugs should be avoided

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