Side effects
of Benzodiazepines
Central
nervous system - headache, drowsiness, excess sedation, impaired coordination,
confusion, anterograde amnesia, euphoria, fatigue
Paradoxical
reactions - increased anxiety, insomnia, hyperexcitability, hallucination
Gastrointestinal
disturbance - nause, vomiting, diarrhea, constipation, dry mouth
Others - BDZs have wide margin of safely if used for
short periods
- prolonged use (beyond several
weeks) may cause Physical Dependence and Psychologic Dependence
- withdrawal syndrome can occur with
BDZs
- tolerance may develop to CNS ADR
and anxiolytic effect upon chronic use
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