Anxiolytics
An
effective anxiolytic agent should reduce anxiety with little or no effect on
motor and mental function
·
Benzodiazepines
(BZDs)
·
Barbiturates
(BARBs)
·
5-HT1A
receptor agonists
·
Carbamates
·
Others:TCAs
(fluvoxamine), MAOIs, Antihistaminicagents, B-Adrenoreceptor antagonists, Antipsychotics
(Ziprasidone)
Overdose
effects of an ideal antianxiety/sedative agent should not include generalized
CNS depression. Therapeutic Index, margin of safety is greater for 2nd
generation agents thatn for 1st generation agents. While increasing the dose,
anxiolytics may give effects of sedation to hypnosis and anesthesia
First
generation - eg. barbiturates
2nd
generation - eg. benzodiazepines
3rd
generation - Selective antianxiety, eg.buspirone
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