Psychomotor
Stimulants
Amphetamine
& related drugs
Amphetamine
Metamphetamine
Methylphenidate
Fenfluramine
Methylenedioxy-metamphetamine
How do they work /
Mechanism of action
Pyschostimulant
drugs have impose marked effect on mental function & behaviour. They can
stimulate specific area of the brain, eg. for amphetamine acts on cerebral
cortex while anorexiants act on hypothalamus and limbic region.
They
act by releasing monoamines from nerve terminals.
They
are also substrate for neuronal uptake transporters especially for
nordarenaline and dopamine. However, fenfluramine and dexfenfluramine
preferentially affect 5-HT (serotonin) release by disrupting vesicular storage
and reverse 5-HT transporter function.
At
lose dose, amphemtamine-related drugs only affect neuronal tranporters while at
high dose, MAO inhibitors are inhibited as well promoting increase level of
noradrenaline and dopamine.
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