Lovastatin Mechanism of Action | How lovastatin works

Lovastatin works by catalyzing the conversion of HMG-CoA to mevalonate by inhibiting competitively HMG-CoA reductase enzyme (or known as 3-hydroxy-3methylglutaryl-coenzyme A reductase). Mevalonate is a precursor and building block for cholesterol biosynthesis and thus would be interfered by lovastatin. Lovastatin is hydrolysed to the beta hydroxy acid form in the body before it becomes active.