Lovastatin was discovered together with compactin in the 1970s since it was found with powerful inhibitory effect on enzyme HMG-CoA reductase which lead to clinical development as potential drugs for lowering LDL cholesterol.
Also, in 1982, There was significant reductions in LDL level observed during small-scale investigations done on lovastatin where it were taken by high-risk patients with concomitantly minimal side effects being observed. Followingly, large-scale clinical trials were done further confirmed the effectiveness of lovastatin in decreaseing LDL cholesterol level where it was approved by US FDA in 1987 due to its good tolerability. Lovastatin was the first statin approved by FDA.
Certain fungi such as Pleurotus species including Pleurotus ostreatus (oyster muschroom) was found to produce lovastatin naturally which was then being researched for its effect of extract animal cholesterol levels.
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