Methadone Side Effects | Arrhythmia | Edema | Thrombocytopenia
Adverse effects of methadone may decrease over several weeks with prolonged administration. However, constipation and sweating may persist.
Cardiovascular: arrhythmia, bigeminal rhythms, radycardia, cardiac arrest, cardiomyopathy,
ECG changes, edema, extrasystoles, faintness, flushing, heart failure, hypotension, palpitation, peripheral vasodilation, phlebitis, orthostatic hypotension, QT interval prolonged, shock, syncope, tachycardia, torsade de pointes, T-wave inversion, ventricular fibrillation, ventricular tachycardia
Central nervous system: Agitation, confusion, disorientation, dizziness, drowsiness, dysphoria, euphoria, hallucination, headache, insomnia, light-headedness, sedation, seizure
Dermatologic: Hemorhagic urticaria, pruritus, rash, urticaria (more common when administered intravenously but are rare side effects)
Endocrine & metabolic: Antidiuretic effect, amenorrhea, hypokalemia, hypomagnesemia, decreased libido
Gastrointestinal: Abdominal pain, anorexia, biliary tract spasm, constipation, glossitis, nausea, stomach cramps, vomiting, weight gain, xerostomia
Hematologic: Thrombocytopenia which is reversible, reported in patients with chronic hepatitis
Neuromuscular & skeletal: weakness
Local (intramuscular or subcutaneous injection): Erythema, pain or swelling.
Ocular Miosis, visual disturbances
Respiratory: Pulmonary edema, respiratory depression, respiratory arrest
Miscellaneous: Death, diaphoresis, physical and psychological dependence
Arrhythmias can occur in healthy individuals with no consequences, but may also ... abdominal distension, fainting, or swelling of the feet and ankles (edema) ... OBJECTIVE: To quantitatively evaluate adverse risks of renal events (renal dysfunction, hypertension, and peripheral edema) and arrhythmia ...
ReplyDeleteSwelling of the ankles or feet ... Headache and edema are the most common side effects. ... Arrhythmia (including ventricular tachycardia and atrial fibrillation), ... Context Adverse effects of selective cyclooxygenase 2 (COX-2) ... edema) and arrhythmia events and to explore drug class effects and temporal ...
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ReplyDeleteThanks for sharing informative post.
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