Methadone Side Effects | Arrhythmia | Edema | Thrombocytopenia
Adverse effects of methadone may decrease over several weeks with prolonged administration. However, constipation and sweating may persist.
Cardiovascular: arrhythmia, bigeminal rhythms, radycardia, cardiac arrest, cardiomyopathy,
ECG changes, edema, extrasystoles, faintness, flushing, heart failure, hypotension, palpitation, peripheral vasodilation, phlebitis, orthostatic hypotension, QT interval prolonged, shock, syncope, tachycardia, torsade de pointes, T-wave inversion, ventricular fibrillation, ventricular tachycardia
Central nervous system: Agitation, confusion, disorientation, dizziness, drowsiness, dysphoria, euphoria, hallucination, headache, insomnia, light-headedness, sedation, seizure
Dermatologic: Hemorhagic urticaria, pruritus, rash, urticaria (more common when administered intravenously but are rare side effects)
Endocrine & metabolic: Antidiuretic effect, amenorrhea, hypokalemia, hypomagnesemia, decreased libido
Gastrointestinal: Abdominal pain, anorexia, biliary tract spasm, constipation, glossitis, nausea, stomach cramps, vomiting, weight gain, xerostomia
Hematologic: Thrombocytopenia which is reversible, reported in patients with chronic hepatitis
Neuromuscular & skeletal: weakness
Local (intramuscular or subcutaneous injection): Erythema, pain or swelling.
Ocular Miosis, visual disturbances
Respiratory: Pulmonary edema, respiratory depression, respiratory arrest
Miscellaneous: Death, diaphoresis, physical and psychological dependence